Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study심각한 동반이환이 있는 고령 인구의 혈청학적 COVID-19 백신 반응 및 내구성과 관련된 특성: 덴마크 전국 ENFORCE 연구Article Published on 2022-08-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] adjusted age antibody baseline ChAdOx1 Characteristics COVID-19 COVID-19 vaccination COVID-19 vaccine declined decrease defined enrolled first vaccination functional hyporesponsiveness identify IgG Immunity increasing age individual interquartile lack Level Male sex median age mRNA vaccine mRNA-1273 number of comorbidity older population outcomes parallel group participant Responder response risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serological Sex spike vaccination. Vaccine vaccine dose vaccine response vaccine-induced antibodies vaccine-induced antibody waned were measured [DOI] 10.1016/j.cmi.2022.03.003 PMC 바로가기 [Article Type] Article
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trialArticle Published on 2022-08-012022-10-06 Journal: Lancet Reg Health Southeast Asia [Category] 진단, [키워드] 1:1 95% CI accelerate accelerated age Anti-viral treatment assessment baseline clearance clinical trial Comorbidities comparable Concentration COVID-19 COVID-19 illness defined demonstrated double-blind Endpoint evaluated funding greater greater transmissibility high risk individuals infected with SARS-CoV-2 Laboratory Limited median Mild multicentre mutate nasal Nasal spray nasal swab nitric oxide nostril parallel group Patient pharmaceutical Placebo placebo-controlled polymerase chain primary analysis population progression proportion provided Randomized randomized trial receiving reduce reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secondary Seven study medication symptomatic the placebo group therapy Treatment treatment difference vaccination Viral load. virus virus clearance virus RNA [DOI] 10.1016/j.lansea.2022.100036 PMC 바로가기 [Article Type] Article
A randomized, controlled, blinded, parallel group, clinical trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India인도의 코비드 전용 병원(DCH)에서 COVID-19 질병 관리를 위한 보조 요법으로서 Ayurcov(AyurCoro3)의 역할을 연구하기 위한 무작위, 통제, 맹검, 병렬 그룹 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Complementary therapies in medicine [Category] SARS, 임상, 치료제, [키워드] adjuvant adverse events alternative medicine alum Antiviral Ayurcov Ayurveda blinded CAM carried Chain Reaction clinical trial complementary Complementary and alternative medicine. control group Controlled trial COVID-19 COVID-19 disease COVID-19 infections Ct values Curcuma Day diagnosed discharge disease dose evaluate Formulation functional Functional status higher risk India ingredient Limited management Mild mild to moderate Mild-to-moderate milk moderate outcome parallel group Patient polymerase chain polymerase chain reaction proportion Randomized real time receiving recruited reduction in regimen resolution of symptom reverse transcriptase Reverse transcriptase polymerase chain reaction Rock Candy rRT-PCR severe COVID-19 disease Severe COVID-19 Infection severe symptoms severity significantly significantly lower significantly more Sita Standard of care Symptom symptom resolution therapeutic effect therapeutic options therapy for COVID-19 transcriptase Treatment Urine [DOI] 10.1016/j.ctim.2022.102824 PMC 바로가기 [Article Type] Randomized Controlled Trial
Satisfaction with modes of telemedicine delivery during COVID-19: A randomized, single-blind, parallel group, noninferiority trialResearch article Published on 2022-07-012022-10-05 Journal: The American journal of the medical sciences [Category] 임상, [키워드] 1:1 95% CI addressed adjusted age analyses Analysis black clinics conducted determine eligible indicated intent-to-treat Intervention majority margin mITT mITT analysis Noninferiority Older outcome parallel group participant Participants Patient satisfaction patients per protocol performed proportion Randomized randomized clinical trial Result Satisfaction single-blind Telemedicine Trial was determined women [DOI] 10.1016/j.amjms.2022.06.021 [Article Type] Research article
Drugs and convalescent plasma therapy for COVID-19: a survey of the interventional clinical studies in Italy after 1 year of pandemicCOVID-19에 대한 약물 및 회복기 혈장 요법: 대유행 1년 후 이탈리아의 중재적 임상 연구 조사Article Published on 2022-06-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 신약개발, 임상, [키워드] 2019 novel coronavirus adopted AIFA Analysis carried Characteristics clinical Clinical research clinical study clinical trial clinical trials convalescent plasma Convalescent plasma therapy coronavirus disease COVID-19 COVID-19 disease Critical disease drug drugs early phase effort Evidence experimental intervention feature Follow-up Health include Intervention investigated investigator investigators Italian Italy landscape majority Medicine methodological Novel coronavirus novel coronavirus disease pandemic parallel group performed platform prevention of COVID-19 Prophylactic Randomized recommendation Registered Replication replications Research Study design therapeutic Therapeutic approach Therapeutic class. therapeutic strategy Treatment Trial trials website were blinded [DOI] 10.1186/s13063-022-06474-8 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
Effects of different doses of methylprednisolone on clinical outcomes in patients with severe community-acquired pneumonia: a study protocol for a randomized controlled trial중증 지역사회획득 폐렴 환자의 임상 결과에 대한 다양한 용량의 메틸프레드니솔론 효과: 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-05-212022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality Chinese clinical Clinical efficacy Clinical outcome clinician community-acquired pneumonia complications Consensus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment determine diagnosed different dose different doses dose dose-dependent double-blind Effect Efficacy Efficacy and safety Endotracheal intubation evaluate Final four group Frequency gastrointestinal hemorrhage glucocorticoid help Hospital stay hyperglycemia ICU interleukin interleukin-6 mechanical ventilation duration Methylprednisolone normal saline Nosocomial infections optimal dose PaO parallel group Patient Placebo placebo-controlled trial Primary outcome protocol randomization Randomized Randomized controlled trial registry SCAP secondary outcome Secondary outcomes serum CRP Severe community-acquired pneumonia. Study protocol temperature treat Treatment Vasopressor vasopressors ventilator-free day Volume [DOI] 10.1186/s13063-022-06404-8 PMC 바로가기 [Article Type] Article
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology rheumatologY. Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Efficacy of Madhav Rasayan Plus as adjuvant in moderate COVID-19 patients: Preliminary Outcomes of Randomized controlled trialShort communication Published on 2022-05-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발, 임상, [키워드] Ayurveda BNP breathlessness clinical trial coagulative complement Complication control group Controlled trial cough COVID-19 COVID-19 disease creatinine phosphokinase CRP disease Diseases fatigue Hospital stay ICU infective Inflammatory marker integrative medicine intervention group Madhav Rasayan plus management marker Moderate COVID-19 organ outcome parallel group patients patients with moderate Pro Quality of life Randomized controlled trial reduced restored reveal severity significantly standard care statistically significant reduction supplemental oxygen symptoms of COVID-19 Tablet tissue Treatment was reduced [DOI] 10.1016/j.jaim.2022.100590 [Article Type] Short communication
Effect of piezocision procedure in levelling and alignment stage of fixed orthodontic treatment: a randomized clinical trial Research Published on 2022-04-142022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] 95% CI adverse effect assigned changes in clinical trial Complete control group Effect effective faster first premolar fixed gingival recession group in both group labial Malaysia malocclusion Mild Orthodontics Pain parallel group participant Patient patients premolar randomization randomized clinical trial Randomized controlled trial Randomly recruited reduction in required Satisfaction sealed significantly shorter study group tissues treated Treatment unit was performed were recorded [DOI] 10.1038/s41598-022-09851-0 [Article Type] Research